NeurIPS 2025 Workshop

Biosecurity Safeguards for Generative AI

Upper Level Room 27AB, San Diego Convention Center, USA

๐ŸŽ–๏ธ Awards

Best Paper: $3,000

Runner-up: $1,000

๐Ÿ† Best Papers

Without Safeguards, AI-Biology Integration Risks Creating Future Pandemics

Dianzhuo Wang ยท Marian Huot ยท Zechen Zhang ยท Kaiyi Jiang ยท Eugene Shakhnovich ยท Kevin Esvelt

GeneBreaker: Jailbreak Attacks against DNA Language Models with Pathogenicity Guidance

Zaixi Zhang ยท Zhenghong Zhou ยท Ruofan Jin ยท Le Cong ยท Mengdi Wang

๐Ÿฅˆ Runner-ups

Deep Ignorance: Filtering Pretraining Data Builds Tamper-Resistant Safeguards into Open-Weight LLMs

Kyle O'Brien ยท Stephen Casper ยท Quentin Anthony ยท Tomek Korbak ยท Robert Kirk ยท Xander Davies ยท Ishan Mishra ยท Geoffrey Irving ยท Yarin Gal ยท Stella Biderman

ABC-Bench: An Agentic Bio-Capabilities Benchmark for Biosecurity

Andrew Liu ยท Samira Nedungadi ยท Bryce Cai ยท Alex Kleinman ยท Harmon Bhasin ยท Seth Donoughe

SafeGenie: Erasing Dangerous Concepts from Biological Diffusion Models

Arjun Banerjee ยท Ethan Tam ยท Camille Dang ยท David Martinez

Resisting RL Elicitation of Biosecurity Capabilities: Reasoning Models Exploration Hacking on WMDP

Joschka Braun ยท Yeonwoo Jang ยท Damon Falck ยท Roland S. Zimmermann ยท David Lindner ยท Scott Emmons

Important Dates

Paper Submission Deadline (OpenReview)
September 10, 2025 AOE
Author Notification:
October 15, 2025
Camera-Ready Deadline:
October 23, 2025
Workshop:
6 December 2025, 9 a.m. PST โ€” 5 p.m. PST

Workshop Overview

AI & the Bio-Revolution: Innovating Responsibly, Securing Our Future

Generative AI is driving a revolution in biotechnology, but with immense potential comes critical biosecurity challenges.

๐Ÿš€ The Promise

GenAI offers unprecedented speed in drug discovery, protein engineering, and synthetic biology.

โš ๏ธ The Peril

These same tools could be misused to design novel pathogens and toxins, amplifying dual-use risks at an alarming pace.

๐Ÿ” The Gap

AI biosecurity is dangerously underexplored, and most generative tools lack built-in safeguards.

๐ŸŽฏ Our Mission

This workshop will unite experts in AI, synthetic biology, biosecurity policy, and ethics to forge actionable solutions. We will move to embed robust, AI-native safeguards directly within the core of these powerful tools.

๐Ÿค Join us to:

  • Engineer next-generation technical guardrails and defenses.
  • Establish benchmarks for risk prediction and red-teaming.
  • Build a global coalition for secure and responsible AI innovation in the life sciences.

Speakers

Yoshua Bengio Mila, Universitรฉ de Montrรฉal
Peter Henderson Princeton University
Jian Ma Carnegie Mellon University
Russ Altman Stanford University
Eric Xing Carnegie Mellon University, MBZUAI, Petuum Inc.
Theofanis Karaletsos Chan Zuckerberg Initiative
Megan Blewett Iris Medicine, Kelonia Therapeutics
Le Cong Stanford University

Workshop Organizers

Mengdi Wang
Princeton University
Le Cong
Stanford University
Amrit Singh Bedi
University of Central Florida
Alvaro Velasquez
University of Colorado Boulder
Zaixi Zhang
Princeton University
Ruofan Jin
Princeton University
Souradip Chakraborty
University of Maryland

Student Organizers

Jigang Fan
Peking University
Zhenghong Zhou
Shanghai Jiao Tong University
Avinash Reddy
University of Central Florida

Sponsors

Nebius Valthos